![]() Results showed that WGS vastly improves our ability to delimit the scope and source of bacterial food-borne contamination events. Results. Phylogenetic analysis of WGS data revealed a common origin for outbreak strains, indicating that patients in Maryland and New York were infected from sources originating at a facility in India.Ĭonclusions. These data represent the first report fully integrating WGS analysis with geographic mapping and a novel use of transmission networks. Pathogen genomes were linked to geography by projecting the phylogeny on a virtual globe and produced a transmission network. Methods. Using next-generation sequencing, we sequenced the complete genome of 100 Salmonella Bareilly isolates obtained from patients who consumed contaminated product, from natural sources, and from unrelated historically and geographically disparate foods. ![]() ![]() ![]() Background. Using a novel combination of whole-genome sequencing (WGS) analysis and geographic metadata, we traced the origins of Salmonella Bareilly isolates collected in 2012 during a widespread food-borne outbreak in the United States associated with scraped tuna imported from India.
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